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KMID : 1035320170440020087
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Korean Society for Dental Materials
2017 Volume.44 No. 2 p.87 ~ p.94
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Antifungal effect and characterization of denture PMMA impregnated with chitosan
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Nam Ki-Young
Shin Young-Min
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Abstract
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In this study, we proposed a modified polymethylmethacrylate (PMMA) denture acrylic impregnated with chitosan as a novel antimicrobial denture base material. We fabricated the samples of chitosan-PMMA denture acrylic (CPD) into four types (1.0 , 3.0 and 5.0 % and 0 %; control) according to the mass fraction (w%) of chitosan blended to pristine PMMA powder with methylmethacrylate (MMA) liquid by the ratio of 1.7 g/ml. For mechanical evaluations, surface morphology, degree of conversion, flexural strength and color changes were tested. The antifungal effects were evaluated in vitro as a number of viable cells (CFU; colony forming unit) in retrieved fungal suspension on samples after 24 hour incubation. A significantly reduced CFU was exhibited at 5.0 % CPD (p < 0.05) by the 40.9 ± 2.1 % inhibitory effect. CPD exhibited the similar microscopic surface texture and no statistical differences (p > 0.05) of the degree of conversion and flexural strength values as compared to pristine PMMA. Color differences were detected at 3.0 and 5.0 % of CPD by the reference value of 2.69. Within the limitation of present study, CPD could be a possible intrinsic antifungal denture material with the proper mechanical characters for a denture biomaterial. For clinical application, future studies including color stability, anti-adherent mechanism and the long-term effect were still required
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